French paediatrician and geneticist, born March 2, 1936, Rabat, Morocco. Claude Griscelli was born in Rabat, Morocco and came to France in 1956. He was an intern at the Paris hospitals in 1962 and in 1972 was appointed professor of paediatrics and medical genetics at the Necker Hospital in Paris. He is a member of several national and international societies in paediatrics, immunology and haematology. Griscelli is an Officier de la Légion d'honneur (1995) and Commandeur dans l'Ordre national du Mérite (2001).
Associated eponyms: Ansell-Bywaters-Elderking syndrome Familial arthropathy with rash, uveitis and mental retardation. Griscelli's syndrome An albinoidism marked by hypomelanosis, frequent pyogenic infection, hepatosplenomegaly, neutro- and thrombopenia, and immunodeficiency.
C. Griscelli, P. Vassalli, R. McCluskey: The distribution of large dividing lymph node cells in syngeneic recipient rats after intravenous injection. The Journal of Experimental Medicine, New York, 1969, 130 (6): 1427-1451.
D. Guy-Grand, C. Griscelli, P. Vassalli: The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions. The Journal of Experimental Medicine, 1978, 148 (6): 1661-1677.
C. Griscelli, A. Durandy, J.L. Virelizier, J.J. Ballet, F. Daguillard: Selective defect of precursor T cells associated with apparently normal B lymphocytes in severe combined immunodeficiency disease. The Journal of Pediatrics, 1978, (3): 404-411.
C. Griscelli, A. Durandy, D. Guy-Grand, F. Daguillard, C. Herzog, M. Prunieras: A syndrome associating partial albinism and immunodeficiency. The American Journal of Medicine, New York, 1978, 65 (4): 691-702.
A. Fischer, J.J. Ballet, C. Griscelli: Specific inhibition of in vitro Candida-induced lymphocyte proliferation by polysaccharidic antigens present in the serum of patients with chronic mucocutaneous candidiasis. The Journal of Clinical Investigation, Ann Arbor MI, November 1978, 62 (5): 1005-1013.
J.L. Virelizier, C. Griscelli: Interferon administration as an immunoregulatory and antimicrobial treatment in children with defective interferon secretion. In: Seligmann, M.; Hitzig, W. H.: Primary Immunodeficiencies. Amsterdam: Elsevier/North Holland Biomedical Press, 1980: 473-484.
J.L. Virelizier, A. Lagrue, A. Durandy, F. Arenzana, C. Oury, C. Griscelli, P. Reinert: Reversal of natural killer defect in a patient with Chediak-Higashi syndrome after bone-marrow transplantation. Letter. The New England Journal of Medicine, 1982, 306: 1055-1056.
E. Vilmer, A. Fischer, C. Griscelli, F. Barre-Sinoussi, V. Vie, J.C. Chermann, L. Montagnier, C. Rouzioux, F. Brun-Vezinet, W. Rosenbaum: Possible transmission of a human lymphotropic retrovirus (LAV) from mother to infant with AIDS. The Lancet, 1984 2 (8396): 229-230.
C. de Préval, B. Lisowska-Grospierre, M. Loche, C. Griscelli, B. Mach: A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes. Nature, 318 (6043): 291-293.
A. Marcadet, D. Cohen, J. Dausset, A. Fischer, A. Durandy, C. Griscelli: Genotyping with DNA probes in combined immunodeficiency syndrome with defective expression of HLA. The New England Journal of Medicine, 1985, 312 (20): 1287-1292.
A. Fischer, J.L. Virelizier, S.F. Arenzana, N. Perez, C. Nezelof, C. Griscelli: Treatment of four patients wth erythrophago¬cytosis by a combination of epipodophyllotoxin, steroids, intracranial methotrexate and cranial irradiation. Pediatrics, 1985, 76: 263-268.
G. de Saint Basile, B. Arveiler, I. Oberlé, S. Malcolm, R.J. Levinsky, Y.L. Lau, M. Hofker, M. Debre, A. Fischer, C. Griscelli: Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13. Proceedings of the National Academy of Sciences of the United States of America, Washington, 1987, 84 (21): 7576-7590.
M. Bejaoui, F. Veber, D. Girault, C. Gaud, S. Blanche, C. Griscelli, A. Fischer: Phase acceleree de la maladie de Chediak-Higashi. Archives francaises de pédiatrie, Paris, 1989, 46: 733-736.
S. Markiewicz, J.P. DiSanto, J. Chelly, N. Fairweather, B. Le Marec, C. Griscelli, M.B. Graeber, U. Müller, A. Fischer, A.P. Monaco: Fine mapping of the human SCIDX1 locus at Xq12-13.1. Human Molecular Genetics, 1993, 2 (6): 651-654.
A. Durandy, J. Breton-Gorius, D. Guy-Grand, C. Dumez, C. Griscelli: Prenatal diagnosis of syndrome associating albinism and immunodefiencies (Chediak Hegashi syndrome and variant). Prenatal Diagnosis, Chichester, Uk, 1993, 13: 13-20.
E. Pastural, F.J. Barrat, R. Dufourcq-Lagelouse, O. Certain S, Sanal, N. Jabado, R. Seger, C. Griscelli, A. Fischer, Geneviève de Saint Basile: Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nature Genetics, New York, 1997, 16 (3): 289-292